Takae Kawamura
Sendai Medical Center Department Anesthesiology Japan

Abstract:

The late preconditioning effect of nitroglycerine(NTG) during cardiac surgery is not clear. The aim of this study is to test whether NTG could attenuate re-perfusion injury in cardiac surgery. 15patients undergoing cardiac surgery allocated randomly into 2 groups(control&, NTG group). 10mg of NTG tapes were pasted to the patients 48hrs before surgery and removed 4hrs.before surgery. Anesthesia was induced by midazolam, fentanyl and rocronium and maintained fentanyl and propofol.

Results: Serum interleukin 8,6in both groups increased significantly from 60 minutes after declamping aorta comparing to the value after anesthetic induction. There were no differences between the two groups. Serum troponin-I, CK-MB and h-FABP increased significantly from 60 minutes after declamping aorta comparing to the value after anesthetic induction. There were no differences between the two groups. Interleukin 8,6, troponin-I, CK-MB and h-FABPin the coronal sinus increased significantly after declamping the aorta comparing to the value of aortic clamping. There were no differences between the two groups.

Conclusion: The late preconditioning effect of nitroglycerine(NTG) during cardiac surgery could not be clarified in this study. It will be necessary to observe in the more cases.